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This is yet another line of evidence suggesting that the amount of cholesterol in LDL particles is not the driving factor in heart disease.
A meta-analysis of statin trials in people without heart disease by the prestigious Cochrane Collaboration came to a similar conclusion.
In a large meta-analysis of 11 randomized controlled trials by Kausik Ray, MD and colleagues published in the Archives of Internal Medicine, statins were not associated with a significant reduction in the risk of death from all causes.
In the third article, I discussed the five primary causes of elevated LDL particle number.They range from 0.8% in MIRACL on the low end to 9% in 4S on the high end, with an average of 3%. David Newman in 2010 which drew on large meta-analyses of statins found that among those with pre-existing heart disease that took statins for 5 years (1): A heart attack or stroke can have a significant negative impact on quality of life, so any intervention that can decrease the risk of such an event should be given serious consideration.But even in the population for which statins are most effective—those with pre-existing heart disease—83 people have to be treated to extend one life, and 39 people have to be treated to prevent a repeat heart attack.In this article, I will debunk the myth that statin drugs save lives in healthy people without heart disease, and discuss some of the little known side effects and risks associated with these drugs.Statins have been hailed by many in the conventional medical establishment as wonder drugs, with some physicians going as far as suggesting they should be added to the water supply.Cardiovascular disease is one of the most misdiagnosed and mistreated conditions in medicine.In the first article in this series, I explained the evidence suggesting that eating cholesterol and saturated fat does not increase the risk of heart disease.(2)Nor do these results apply to men or women over the age of 80.Statins do reduce the risk of heart attack and other CVD events in men over the age of 80, and especially at this age, these events can have a significant negative impact on quality of life.The lack of significant effect on mortality is even more interesting in light of the fact that LDL cholesterol levels did decrease significantly in the statin group; the average LDL level in those taking placebo was 134 mg/d L and the average in the statin-treated patients was 94 mg/d L—roughly 30% lower.Yet in spite of this marked reduction in LDL cholesterol in the statin group, there was no difference in lifespan between the two groups.